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Weight Loss Efficacy: advantage goes to MariTide

Semaglutide: Targets the GLP-1 pathway only Focuses on appetite regulation and fullness Tirzepatide: Targets both GLP-1 and GIP pathways May create a broader metabolic response Although this difference sounds technical, it can influence how patients respond to treatment

Cholesterol impact represents the primary concern, with HDL cholesterol often decreasing while LDL may increase

It is attributed to the causation of 6% of cases of ESRD in the USA and has become the 4th leading cause of ESRD in adult patients in the European Union (Chebib and Torres 2016

The study was only studied over one year time frame

There were four suicides in AED-treated patients in the trials and none in placebo-treated patients, but the number is too small to allow any conclusion about AED effect on suicide