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High doses of turmeric and curcumin are not recommended long-term since research confirming their safety is lacking

When the active substance circulates via the bloodstream, a fraction of the active substance will be metabolized or excreted, and consequently the concentration of the active substance in the body will decrease over time (see figure above)

These factors contribute to increased oxidative stress, leading to an increased demand for Glutathione to counteract the damaging effects of free radicals