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Sci Rep 13 , 8778 (2023)

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Read: #Biotech #LifeSciences #MedTech #Pharma #Innovation To view or add a comment, sign in Promising Clinical Trial Results for Cardiomyopathy Target Disease: non-obstructive hypertrophic cardiomyopathy - a disease where the heart muscle thickens and becomes stiff, which makes circulation more difficult Company: Cytokinetics Treatment: Myqorzo (aficamten) About Myqorzo - Inhibits cardiac myosin to make cardiomyocyte contractions less forceful Study Design Phase 3 trial 24 weeks double blind, randomized, placebo-controlled 282 patients total (142 in treatment group, 140 controls) Results Myqorzo met the two main objectives of the study: the treatment group had improved peak oxygen consumption and better heart health scores after 36 weeks Not without side effects: 27 in the treatment group and 1 control experienced a significant drop in the amount of blood pumped through arteries Myqorzo was associated with heart failure in two patients

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