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Patients start by taking a small dose of either medication to limit side effects, then gradually increase their dosage over time

There is little high-quality guidance, while interclass differences (i.e

6A) AngII increased the expression level of Ctgf and Col3a1 as markers of fibrosis, compared to Sham-operated animals, whereas TZP and Lira significantly decreased the expression level of these markers in the AngII-induced groups (Fig

It's a chronic treatment for as long as it's beneficial and safe: the doctor reviews your response every 3 months and decides with you whether to continue, adjust or stop

The tradeoff with lower concentrations is that you need more liquid per dose, which means larger injection volumes and faster vial depletion