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It improves mitochondrial function, AMPK activity, and insulin sensitivity

Whereas previous research has demonstrated the feasibility of using peptides to target nuclear hormone receptors 46,47 , to our knowledge, this is the first single molecule that uses a G-protein-coupled-receptor targeting approach to deliver a small-molecule modulator of an ionotropic receptor

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In addition, GLP-1 activates stretch receptors in the small intestine, which in turn signal to the hypothalamus to reduce appetite and increase energy expenditure

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doi: 10.1016/0005-2736(77)90402-3