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GLP-1 is a kinked but continuous alpha-helix from Thr(13) to Val(33) when bound to the extracellular domain

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The blood sugar may not drop dangerously low (true hypoglycemia on tirzepatide monotherapy is rare), but even mild fluctuations can trigger the sympathetic nervous system enough to cause brief awakenings

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The GLP-1/GIP dual agonist tirzepatide effectively reduced tumor growth in both obese and lean mice, and improved obesity-associated serum adiponectin, leptin and C-reactive protein levels in obese mice (69)