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Regulatory status (as of publication): Not approved by the FDA, EMA, or any other regulatory authority for any indication

However, clinical trials have shown that significant weight loss can be achieved within the first few months of treatment

Constipation occurs less common than diarrhea, and may alternate with periods of loose stools in some individuals

You may be a candidate if you have: A body mass index (BMI) of 30 or higher A BMI of 27 or higher with weight-related health problems like high blood pressure or type 2 diabetes Difficulty losing weight through diet and exercise alone Your family doctor in Irving, TX, will evaluate your complete medical history before recommending either medication

For weight loss , tirzepatide set a new benchmark for approved therapy, and retatrutide's Phase 2 results suggest it may push that benchmark higher still

However, male weight loss often plateaus earlier than female loss, typically around weeks 28-32 versus weeks 32-36 for women