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A dysregulation of GSH synthesis is recognized as contributing factor to the pathogenesis of many pathological conditions

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10.1152/ajplung.00051.2016 57 ZhangR.BrennanM.ShenZ.MacPhersonJ.SchmittD.MolendaC.et al (2002)

Desensitization of the permeability transition pore by cyclosporin a prevents activation of the mitochondrial apoptotic pathway and liver damage by tumor necrosis factor-alpha

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RNA-based silencing (RNAi/miRNA) RNA interference techniques use small RNA molecules (siRNA, miRNA) to silence the expression of pathogenic genes post-transcriptionally, such as genes involved in autoimmune antigen presentation or proinflammatory signaling