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Ubiquitin modifications control a plethora of vital cellular processes through proteolytic and nonproteolytic mechanisms, including proteasomal degradation and proteostasis, selective autophagy, cell signalling cascades such as those for NF-B activation, protein trafficking, DNA repair and genome integrity, cell cycle control, and programmed cell death (Fig

They must be reconstituted before use.

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Flavonoids in green tea have been shown to regulate the expression of pro-inflammatory genes that target TLRs and inhibit downstream MyD88- and Toll/IL-1R domain-containing adaptor-inducing IFN- (TRIF)-dependent signaling pathways (89)

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