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Other evidence suggests the L-cells located in the proximal jejunum are sufficient to account for the early-phase secretion through direct contact with luminal nutrients

Combining these can lead to a dangerous drop in blood pressure

10.1007/s40261-022-01202-1 38 XiongS.GouR.LiangX.WuH.QinS.LiB.et al (2024)

The vascular-modulating component, carrier pharmacokinetics and payload release profile need to be coordinated with the normalization window

Upon reaching the tumor site, stealth liposomes primarily remain within the extracellular matrix rather than entering tumor cells directly

But the preclinical evidence provides a powerful rationale for undertaking that work