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Gemcitabine - CAS# 95058-81-4 Catalog No.:M10648-2 PD146176 inhibits 13-HODE production with

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Gemcitabine - CAS# 95058-81-4 Catalog No.:M10648-2 PD146176 inhibits 13-HODE production withGemcitabine is an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Product information CAS

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Description

PD146176 inhibits 13-HODE production with an IC50 of 0

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6-dimethoxy-3-methylcyclohexa-2

Gemcitabine - CAS# 95058-81-4 Catalog No.:M10648-2 PD146176 inhibits 13-HODE production withGemcitabine is an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Product information CAS

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