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Introduction Irritable bowel syndrome (IBS) is a prevalent and debilitating gastrointestinal condition characterized by recurrent flare-ups of symptoms such as increased central pain, bloating, diarrhea, and constipation ( Post-viral gastroenteritis, pre-morbid psychological disorders, and the hypothalamic-pituitary-adrenal axis mediate a maladaptive stress response, which is essential for the onset, intensity, and persistence of IBS-associated symptoms ( The Rome IV diagnostic criteria are currently used to diagnose IBS, which is divided into four subgroups based on bowel habits, bowel function, and stool consistency: constipation dominant (IBS-C), diarrhea dominant (IBS-D), mixed (IBS-M), and unclassified/unspecified IBS (IBS-U) ( Following food consumption, the metabolic endocrine cascade begins with gastric emptying

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Dyskinesias Another complication of L-dopa therapy is on period dyskinesias (involuntary choreiform movements involving usually the neck, trunk, and lower/upper extremities)

This helped to show that NNMT is a key target in metabolic research. Neelakantan and colleagues then expanded research involving small-molecule NNMT inhibitors