humanized glp-1 receptor knock-in mouse Distinct Neural Sites of GLP-1R Expression Mediate Physiological versus Pharmacological Control of Incretin Action: Cell Reports Enhanced plasma half-life and efficacy

Name: humanized glp-1 receptor knock-in mouse Distinct Neural Sites of GLP-1R Expression Mediate Physiological versus Pharmacological Control of Incretin Action: Cell Reports Enhanced plasma half-life and efficacy
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Enhanced plasma half life and efficacy of engineered human albumin fused GLP 1 despite enzymatic cleavage of its C terminal end Communications Biology Generation and characterisation of a humanised GLP 1 receptor mouse model for translational drug development eBioMedicine Chronic treatment with glucagon like peptide 1 and glucagon receptor co agonist causes weight loss independent improvements in hepatic steatosis in mice with diet induced obesity ScienceDirect GLP 1 Orals and Multi Agonists: Advancing Next Gen Weight Loss Therapies with Humanized Models JCI Transcriptome guided GLP 1 receptor therapy rescues metabolic and behavioral disruptions in a Bardet Biedl syndrome mouse model The Obesity Science & Innovation 2025: Generation of Humanized GIPR Mice for Obesity and Diabetes Preclinical

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Description

BMJ, 2024

We look for objective support for the alleged injury (such as specialist diagnoses, imaging, motility testing, and ophthalmology evaluations) so the case can be assessed on evidence, not speculation

Research has spanned gastrointestinal, musculoskeletal, and neurological model systems