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We observed comparable liver luciferase (Luc) activity between LNP and hydrodynamic (HD) injection, a method well-known for its high liver transfection efficiency (Supplementary Fig

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In mice and rats, standard two-year carcinogenicity studies with insulin glargine were performed at doses up to 0.455 mg/kg, which was for the rat approximately 65 times the recommended human subcutaneous starting dosage of 0.2 units/kg/day (0.007 mg/kg/day) on a mg/kg basis