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(2019) 31:e1904197

Experimental studies reveal that MNPs induce oxidative stress, inflammation, mitochondrial dysfunction and cell death in cardiac cells, potentially contributing to myocardial damage, fibrosis and maladaptive remodelling

This helps protect patients from unproven or potentially dangerous treatments and ensures that the treatments offered have some scientific evidence of safety and efficacy

The receptor itself couples to multiple G proteins (Gq/11, Gi/o, G12/13, and -arrestin), and different agonists can bias signaling toward different pathways (Overlapping binding site study, 2008)

Acknowledgements This work was partly supported by Associazione Italiana Ricerca sul Cancro (AIRC) (IG2014-15197 to L.F.) and by grants from the University of Chieti-Pescara G