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Semaglutide, a GLP-1 receptor agonist originally developed for type 2 diabetes, produces significant weight loss in most patients when combined with consistent nutrition and activity changes

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Notably, MCP-1, also known as chemokine ligand 2 (CCL2), plays a pivotal role in promoting BBB instability by facilitating the recruitment of monocytes/Ms into CNS compartment and contributing to the reorganization of TJ and the actin cytoskeleton (Stamatovic et al., 2003)

Individuals with a family history of diabetes are also at higher risk

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