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Consequently, tailored nutritional strategies including abbreviated fasting protocols and personalized micronutrient supplementation warrant exploration as adjunctive therapies for PND management, particularly targeting neuroinflammatory cascades

Indirectly, oncogenic Rho GTPase signaling activates JNK (c-Jun N-terminal kinase), which phosphorylates and stabilizes c-Jun, forming a coherent JNK/cJun/GLS promoter axis that amplifies GLS expression and promotes glutamine metabolism in breast cancer cells (90)

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[88] [89] Additionally, carotenoids such as lutein and zeaxanthin found in the retina affect eye health from early development to aging, impacting conditions like ROP and AMD

As the metabolic therapeutics market expands, selecting a supplier that aligns with specific procurement parameterspurity, compliance, customization, and logisticswill be critical to ensuring product success and regulatory acceptance

*Correspondence: Kei-ichiro Arimoto, [email protected]