GLP-1 receptor agonists in women with PCOS: A systematic review and meta-analysis
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Given that the Peptide group mimics conventional peptide therapeutics, we anticipate that genome editing-mediated Exe4 secretion could provide similar efficacy to existing GLP-1RA treatments
6 Current strategies for modulating gut microbiota The current strategies for modulating gut microbiota include fecal microbiota transplantation (FMT), live biotherapeutic productions (LBPs), probiotics, prebiotics, symbiotics, dietary interventions, gut microbiota enzyme inhibition, and microbial-drug interactions ( Figure 4 ) (Schneiderhan et al., 2016
Alcohol metabolizing enzymes, microsomal ethanol oxidizing system, cytochrome P450 2E1, catalase, and aldehyde dehydrogenase in alcohol-associated liver disease
Dietary and lifestyle strategies include: Eating smaller, more frequent meals rather than large portions, which reduces gastric distension Avoiding carbonated drinks and foods that produce excess gas (e.g., beans, cruciferous vegetables, onions) Eating slowly and chewing thoroughly to minimise air swallowing (aerophagia) Limiting high-fat foods , which further delay gastric emptying and may worsen symptoms Staying upright after meals for at least 3060 minutes to facilitate digestion Avoiding tight clothing around the abdomen that may increase intra-abdominal pressure Medication management considerations include: Following the recommended dose titration schedule (typically starting at 0.25 mg weekly for four weeks, then 0.5 mg weekly, with potential increases to 1 mg and then 2 mg if needed and tolerated) to allow gradual adaptation Taking Ozempic at a consistent time each week, preferably when dietary intake can be monitored Discussing with your GP, pharmacist or diabetes specialist nurse whether temporary use of over-the-counter remedies such as simeticone (for gas relief) or alginates (for reflux symptoms) might be appropriate Maintaining adequate hydration, particularly if experiencing nausea or diarrhoea Patients should maintain open communication with their healthcare team throughout treatment
