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From Diabetes Treatment to Obesity Medicine: Semaglutide's Evolution Semaglutide was originally developed as a once-weekly injectable GLP-1 receptor agonist for type 2 diabetes management, receiving FDA approval in December 2017 under the brand name Ozempic

As a result, there is a greater demand for GLP-1 drugs like Wegovy (semaglutide), Saxenda (liraglutide), and Mounjaro (tirzepatide)

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Under conditions of oxidative stress, excess H 2 O 2 and O 2 can increase the phosphorylation levels of RIPK1 and RIPK3, activating MLKL and inducing membrane rupture [237]